产品货号：
Z12461
中文名称：
CAMKK1抗体
英文名称：
Anti-CAMKK1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CAMKK1 Antibody |
| 指标别名 | CaM kinase IV kinase;CaM kinase kinase 1;CaM kinase kinase alpha;CaM KK 1;CaM KK alpha;CaMKK 1;CaMKK alpha;CAMKK1;CAMKKA |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | CAMKK1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of mouse CaMKK(10-31aa QDPRAELVDRVAAINVAHLEEA),different from the related human sequence by three amino acids,and from the related rat sequence by two amino acids. |
| 实际分子量 | 56KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CAMKK1,Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene.The CAMKK1 gene is mapped to chromosome 17.The product of this gene belongs to the Serine/Threonine protein kinase family,and to the Ca(2+)/calmodulin-dependent protein kinase subfamily.This protein plays a role in the calcium/calmodulin-dependent(CaM) kinase cascade.Three transcript variants encoding two distinct isoforms have been identified for this gene.Camkk1binds calmodulin and activated Camk4 with a 6-fold increase in total activity and a 100-fold increase in Camk4 Ca(2+)-independent activity.Camkk1 catalyzed a 10-fold increase in the total activity of Camk1 and had no effect on Camk2.Cotransfection of COS-7 cells with Camkk1 and Camk4 resulted in a 14-fold increase in CRE-binding protein-dependent transcription compared with Camk4 alone,suggesting that Camkk1 enhances Camk4-mediated transcriptional regulation. |
| Uniprot ID | Q8VBY2 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | calcium/calmodulin-dependent protein kinase kinase 1,alpha |
| 蛋白名全称 | Calcium/calmodulin-dependent protein kinase kinase 1(CaM-KK 1/CaM-kinase kinase 1/CaMKK 1) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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